Trends in prevention of glucocorticoid-induced osteoporosis

J Rheumatol. 2006 Aug;33(8):1651-7.

Abstract

Objective: To determine longitudinal patterns and predictors for the utilization of bone mass measurements and anti-osteoporotic medications in the prevention of glucocorticoid-induced osteoporosis.

Methods: Within a managed care population of 7 million persons, we identified 3,125 adult men and women who had initiated longterm glucocorticoid therapy (>or=7.5 mg/day of prednisone equivalent for > 6 mo). The study population was examined by 3 biennial intervals between years 1996 and 2001 for receipt of a bone mass measurement and use of anti-osteoporotic medication (bisphosphonate, calcitonin, raloxifene, hormone replacement therapy).

Results: Receipt of a bone mass measurement increased among postmenopausal women from 10% in 1996-97 to 19% in 2000-01, but remained below 6% in all biennial intervals among women under age 50 and men. The use of anti-osteoporotic medication was most common among postmenopausal women, where it approached 50%. The largest absolute increase in anti-osteoporotic medication utilization was among women ages 65 and over, increasing from 24% in 1996-97 to 44% in 2000-01. The specialty of physician providing care was associated with receipt of both testing and treatment. Odds of receipt of a bone mass measurement and anti-osteoporotic medication were 3 to 4 times greater among patients of rheumatologists compared to those of internists or family practitioners.

Conclusion: Among patients initiating longterm glucocorticoid therapy, the proportion of individuals receiving a bone mass measurement or anti-osteoporotic medication remains relatively low, but has improved temporally among postmenopausal women.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Bone Density / drug effects
  • Bone Density Conservation Agents / therapeutic use*
  • Female
  • Glucocorticoids / adverse effects*
  • Humans
  • Male
  • Middle Aged
  • Osteoporosis / chemically induced*
  • Osteoporosis / prevention & control*
  • Postmenopause
  • Prednisone / adverse effects*
  • Professional Practice
  • Rheumatology / trends*

Substances

  • Bone Density Conservation Agents
  • Glucocorticoids
  • Prednisone