Reduction in bioavailability of 6-mercaptopurine on simultaneous administration with cow's milk

Pediatr Hematol Oncol. 2006 Sep;23(6):485-7. doi: 10.1080/08880010600796095.

Abstract

The authors present a case where the simultaneous administration of 6-mercaptopurine (6-MP) and cow's milk during maintenance treatment for acute lymphoblastic leukemia led to elevated full blood counts resistant to increasing doses of chemotherapy. The blood counts returned to the expected range after milk intake with chemotherapy was discontinued.

Publication types

  • Case Reports

MeSH terms

  • Animals
  • Antineoplastic Agents / therapeutic use
  • Biological Availability
  • Child, Preschool
  • Humans
  • Leukocyte Count
  • Male
  • Mercaptopurine / administration & dosage*
  • Mercaptopurine / pharmacokinetics*
  • Methotrexate / therapeutic use
  • Milk*
  • Neutrophils / cytology
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*

Substances

  • Antineoplastic Agents
  • Mercaptopurine
  • Methotrexate