Forced exercise does not improve recovery after hemorrhagic stroke in rats

Brain Res. 2006 Sep 13;1109(1):183-91. doi: 10.1016/j.brainres.2006.06.035. Epub 2006 Jul 18.

Abstract

Exercise can improve recovery following ischemia and intracerebral hemorrhage (ICH) in rodents. We tested whether forced exercise (EX; running wheel) prior to and/or following ICH in rats would reduce lesion volume and improve functional outcome (walking, skilled reaching, spontaneous paw usage) at 7 weeks post-ICH. A striatal hemorrhage was produced by infusing collagenase. First, we compared animals that received EX (2 weeks; 1 h/day) ending two days prior to ICH and/or starting two weeks following ICH. EX did not improve functional recovery or affect lesion size. Doubling the amount of EX given per day (two 1-h sessions) both prior to and following ICH did not alter lesion volume, but worsened recovery. We then determined if EX (1 h/day) prior to and following ICH would affect outcome after a somewhat milder insult. There were no differences between the groups in lesion volume or recovery. Finally, we used a hemoglobin assay at 12 h following ICH to determine if pre-stroke EX (2 weeks; 1 h/day) aggravated bleeding. It did not. These observations suggest that EX does not improve outcome when given prior to and/or when delayed following ICH. Effective rehabilitation for ICH will likely require more complex interventions than forced running.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analysis of Variance
  • Animals
  • Behavior, Animal
  • Collagenases
  • Disease Models, Animal
  • Food Deprivation / physiology
  • Functional Laterality / physiology
  • Intracranial Hemorrhages / chemically induced
  • Intracranial Hemorrhages / complications
  • Intracranial Hemorrhages / rehabilitation
  • Male
  • Motor Activity / physiology
  • Physical Conditioning, Animal / methods*
  • Psychomotor Performance / physiology
  • Rats
  • Rats, Long-Evans
  • Recovery of Function / physiology*
  • Stroke / etiology
  • Stroke / pathology
  • Stroke Rehabilitation*
  • Time Factors

Substances

  • Collagenases