Abstract
A new triterpenoid saponin, 3-O-[(3-O-alpha-l-arabinofuranosyl-2-O-beta-d-galactopyranosyl)-beta-d-glucuronopyranosyl]-21,22-di-O-angeloyl-R1-barrigenol (1), together with four known triterpenoids, have been isolated from the husks of Xanthoceras sorbifolia Bunge. Their structures were elucidated based on chemical and spectral analysis. Among them, 1 was found to have activity of inhibiting the proliferation of six human tumour cell lines (IC50 10-40 mug/ml).
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / pharmacology
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Humans
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Inhibitory Concentration 50
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Molecular Structure
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Sapindaceae / chemistry*
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Saponins / chemistry*
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Saponins / isolation & purification
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Saponins / pharmacology
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Triterpenes / chemistry*
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Triterpenes / isolation & purification
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Triterpenes / pharmacology
Substances
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3-O-((3-O-alpha-l-arabinofuranosyl-2-O-beta-d-galactopyranosyl)-beta-d-glucuronopyranosyl)-21,22-di-O-angeloyl-R1-barrigenol
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Antineoplastic Agents, Phytogenic
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Saponins
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Triterpenes