Polymorphism in the CYP2D6 tamoxifen-metabolizing gene influences clinical effect but not hot flashes: data from the Italian Tamoxifen Trial

J Clin Oncol. 2006 Aug 1;24(22):3708-9; author reply 3709. doi: 10.1200/JCO.2006.06.8072.
No abstract available

Publication types

  • Comment
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Anticarcinogenic Agents / metabolism*
  • Antineoplastic Agents, Hormonal / metabolism*
  • Breast Neoplasms / genetics
  • Breast Neoplasms / prevention & control*
  • Cytochrome P-450 CYP2D6 / genetics*
  • Estrogen Receptor Modulators / metabolism*
  • Female
  • Gene Frequency
  • Genotype
  • Hot Flashes / prevention & control*
  • Humans
  • Italy
  • Middle Aged
  • Polymorphism, Genetic*
  • Randomized Controlled Trials as Topic
  • Tamoxifen / metabolism*

Substances

  • Anticarcinogenic Agents
  • Antineoplastic Agents, Hormonal
  • Estrogen Receptor Modulators
  • Tamoxifen
  • Cytochrome P-450 CYP2D6