Abstract
A number of new 6-substituted 3-(pyridine-4-yl) 1,2,4-triazole[3,4-b][1,3,4]thiadiazoles were synthesized and evaluated for their pharmacological activity. Some of them exhibited moderate MAO, antimalarial and in vitro antitumor activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Anxiety Agents / pharmacology
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Antimalarials / chemical synthesis*
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Antimalarials / pharmacology
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology
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Antiparkinson Agents / pharmacology
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Bacteria / drug effects
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Brain / drug effects
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Brain / enzymology
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Cerebral Cortex / drug effects
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Cerebral Cortex / enzymology
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In Vitro Techniques
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Kidney / drug effects
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Kidney / enzymology
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Mice
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Microbial Sensitivity Tests
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Monoamine Oxidase Inhibitors / chemical synthesis*
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Monoamine Oxidase Inhibitors / pharmacology
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Plasmodium falciparum / drug effects
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Pyridines / chemical synthesis*
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Pyridines / pharmacology
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Rats
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Thiadiazoles / chemical synthesis*
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Thiadiazoles / pharmacology
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Triazoles / chemical synthesis*
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Triazoles / pharmacology
Substances
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Anti-Anxiety Agents
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Antimalarials
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Antineoplastic Agents
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Antiparkinson Agents
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Monoamine Oxidase Inhibitors
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Pyridines
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Thiadiazoles
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Triazoles