Abstract
Neurotensin (NT) is a 13-amino acid neuropeptide found in the central nervous system and in the gastrointestinal tract. It is closely associated anatomically with dopaminergic and other neurotransmitter systems, and evidence supports a role for NT agonists in the treatment of various neuropsychiatric disorders. However, NT is readily degraded by peptidases, so there is much interest in the development of stable NT agonists, that can be injected systemically, cross the blood-brain barrier (BBB), yet retains the pharmacological characteristics of native NT for therapeutic use in the treatment of diseases such as schizophrenia, Parkinson's disease and addiction.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antipsychotic Agents / pharmacology
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Behavior, Animal / drug effects
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Central Nervous System / drug effects*
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Central Nervous System / physiology
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Dopamine / metabolism
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Humans
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Illicit Drugs
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Neurotensin / analogs & derivatives*
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Neurotensin / antagonists & inhibitors
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Neurotensin / pharmacology
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Parkinsonian Disorders / drug therapy
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Parkinsonian Disorders / physiopathology
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Pituitary Hormones, Anterior / metabolism
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Psychotropic Drugs / pharmacology
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Receptors, Neurotensin / agonists
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Receptors, Neurotensin / drug effects
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Receptors, Neurotensin / physiology
Substances
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Antipsychotic Agents
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Illicit Drugs
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Pituitary Hormones, Anterior
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Psychotropic Drugs
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Receptors, Neurotensin
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Neurotensin
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Dopamine