A polymeric micelle MRI contrast agent with changeable relaxivity

J Control Release. 2006 Sep 12;114(3):325-33. doi: 10.1016/j.jconrel.2006.05.030. Epub 2006 Jun 15.

Abstract

Polymeric micelles were formed from cationic polymers (polyallylamine or protamine) and anionic block copolymers (poly(ethylene glycol)-b-poly(aspartic acid) derivative) that bound Gd ions providing high contrasts in Magnetic Resonance Imaging (MRI) by shortening the T(1) longitudinal relaxation time of protons of water. The Gd-binding block copolymer alone showed high relaxivity (T(1)-shortening ability) values from 10 to 11 mol(-1) s(-1), while the polymeric micelles exhibited low relaxivity values from 2.1 to 3.6 mol(-1) s(-1). These findings point to the feasibility of a novel MRI contrast agent that selectively provides high contrasts at solid tumor sites owing to a dissociation of the micelle structures, while selective delivery to the tumor sites is achieved in the polymeric micelle form.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Contrast Media / administration & dosage*
  • Contrast Media / chemistry
  • Gadolinium DTPA / administration & dosage*
  • Gadolinium DTPA / chemistry
  • Magnetic Resonance Imaging*
  • Micelles*
  • Neoplasms / diagnosis
  • Polymers / administration & dosage*

Substances

  • Contrast Media
  • Micelles
  • Polymers
  • Gadolinium DTPA