The aims of this study were to assess the frequency and impact of psychiatric symptoms among adolescents with epilepsy in a general population, and compare the findings with those for adolescents without epilepsy. The data were collected through the Health Profiles for Children and Youth in Akershus Study. The data were cross-sectional and based on self-reports from adolescents (13-16 years of age). To assess psychiatric symptoms, we used the Strengths and Difficulties Questionnaire-Self Report (SDQ-S). A total of 11,021 pupils were invited to participate, and 9424 responded to the questionnaire (response rate=86%). We found that adolescents with epilepsy (124) from an unselected group obtained a significantly higher symptom score on the SDQ-S than those without epilepsy, indicating a higher incidence of psychiatric symptoms. The adolescents with epilepsy also reported a greater impact of their perceived difficulties on their daily life than did adolescents without epilepsy. The study illustrates the need for developing better strategies to detect and prevent psychiatric problems in adolescents with epilepsy.