Sensing by bacterial regulatory systems in host and non-host environments

Eduardo A Groisman; Chakib Mouslim

doi:10.1038/nrmicro1478

Sensing by bacterial regulatory systems in host and non-host environments

Nat Rev Microbiol. 2006 Sep;4(9):705-9. doi: 10.1038/nrmicro1478. Epub 2006 Aug 7.

Authors

Eduardo A Groisman¹, Chakib Mouslim

Affiliation

¹ Department of Molecular Microbiology, Washington University School of Medicine, Campus P.O. Box 8230, 660 South Euclid Avenue, St. Louis, Missouri 63110, USA. [email protected]

PMID: 16894339
DOI: 10.1038/nrmicro1478

Abstract

Free-living organisms have the ability to gauge their surroundings and modify their gene expression patterns in ways that help them cope with new environments. Here we discuss the physiological significance of recent reports describing the ability of the Salmonella typhimurium PhoP/PhoQ two-component system to recognize and respond to host-derived antimicrobial peptides.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Animals
Antimicrobial Cationic Peptides / metabolism*
Bacterial Physiological Phenomena
Bacterial Proteins / genetics
Bacterial Proteins / metabolism*
Gene Expression Regulation, Bacterial*
Humans
Salmonella typhimurium / genetics*
Salmonella typhimurium / physiology*
Signal Transduction

Substances

Antimicrobial Cationic Peptides
Bacterial Proteins
PhoQ protein, Bacteria
PhoP protein, Bacteria