CagA-producing Helicobacter pylori and increased risk of gastric cancer: a nested case-control study in Korea

J Gwack; A Shin; C-S Kim; K-P Ko; Y Kim; J K Jun; J Bae; S K Park; Y-C Hong; D Kang; S-H Chang; H-R Shin; K-Y Yoo

doi:10.1038/sj.bjc.6603309

CagA-producing Helicobacter pylori and increased risk of gastric cancer: a nested case-control study in Korea

Br J Cancer. 2006 Sep 4;95(5):639-41. doi: 10.1038/sj.bjc.6603309. Epub 2006 Aug 8.

Authors

J Gwack¹, A Shin, C-S Kim, K-P Ko, Y Kim, J K Jun, J Bae, S K Park, Y-C Hong, D Kang, S-H Chang, H-R Shin, K-Y Yoo

Affiliation

¹ Department of Preventive Medicine, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul, 110-799, Korea.

Abstract

In a nested-case control study of 100 cases of gastric cancer and 400 matched controls in relation to virulence factors of Helicobacter pylori in a Korean cohort, CagA seropositivity was significantly associated with a higher risk of gastric cancer among H. pylori-infected subjects (OR=3.57, 95% CI 1.05-12.14).

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Alcohol Drinking
Antigens, Bacterial
Bacterial Proteins
Case-Control Studies
Female
Helicobacter Infections / complications*
Helicobacter Infections / epidemiology
Helicobacter pylori / genetics
Helicobacter pylori / isolation & purification*
Helicobacter pylori / pathogenicity
Humans
Korea / epidemiology
Male
Middle Aged
Risk Factors
Smoking
Stomach Neoplasms / epidemiology*
Stomach Neoplasms / microbiology*
Virulence

Substances

Antigens, Bacterial
Bacterial Proteins
cagA protein, Helicobacter pylori