Abstract
Basal 5-hydroxytryptamine (5HT) and norepinephrine (NE) concentrations were measured in samples collected by in vivo dialysis of the rat dorsal horn. Infusion of KCl, glutamate, and NE by means of the dialysis probe increased NE, but decreased 5HT extracellular concentrations. In contrast, electrical stimulation of the nucleus raphe magnus increased the recovery of both NE and 5HT. These findings suggest differential regulation of noradrenergic and serotonergic nerve terminals modulating nociceptive neurotransmission within the dorsal horn.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Anesthesia
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Animals
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Chloral Hydrate
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Dialysis
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Electric Stimulation
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Glutamates / pharmacology
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Hydroxyindoleacetic Acid / metabolism
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Male
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Norepinephrine / metabolism*
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Norepinephrine / pharmacology
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Potassium Chloride / pharmacology
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Raphe Nuclei / physiology
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Rats
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Rats, Inbred Strains
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Serotonin / metabolism*
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Spinal Cord / anatomy & histology
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Spinal Cord / drug effects
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Spinal Cord / metabolism*
Substances
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Glutamates
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Serotonin
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Chloral Hydrate
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Hydroxyindoleacetic Acid
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Potassium Chloride
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Norepinephrine