Synthesis and purification of two SP (6-11) analogues with enhanced selectivity for the NK-1 receptor

I Haro; J L Torres; G Valencia; J M Garcia Anton; F Reig

doi:10.1111/j.1399-3011.1990.tb00246.x

Synthesis and purification of two SP (6-11) analogues with enhanced selectivity for the NK-1 receptor

Int J Pept Protein Res. 1990 Feb;35(2):123-7. doi: 10.1111/j.1399-3011.1990.tb00246.x.

Authors

I Haro¹, J L Torres, G Valencia, J M Garcia Anton, F Reig

Affiliation

¹ Laboratory of Peptides, Biological Organic Chemistry Department, C.I.D., C.S.I.C., Barcelona, Spain.

PMID: 1691155
DOI: 10.1111/j.1399-3011.1990.tb00246.x

Abstract

Two hexapeptide analogues of Substance P (6-11) have been synthesized. Replacement of Gly9 by proline provides a peptide with tenfold enhanced selectivity for the NK-1 receptor. The corresponding proline-containing glycopeptide incorporating a beta-D-glucopyranosyl residue linked to the side-chain of Glu6 was 100 times more selective than Substance P for the same receptor.

MeSH terms

Chemical Phenomena
Chemistry
Chromatography, High Pressure Liquid
Humans
Peptide Fragments*
Pyrrolidonecarboxylic Acid / analogs & derivatives
Receptors, Neurotransmitter*
Receptors, Tachykinin
Substance P*

Substances

Peptide Fragments
Receptors, Neurotransmitter
Receptors, Tachykinin
Substance P
substance P (6-11)
Pyrrolidonecarboxylic Acid