Aging: progeria and the lamin connection

Curr Biol. 2006 Aug 22;16(16):R652-4. doi: 10.1016/j.cub.2006.07.029.

Abstract

The relationship between progerias--diseases that resemble premature aging--and the normal aging process has been a source of debate in the aging research community. A recent study finds that LMNA, a gene targeted for mutation in Hutchinson Gilford Progeria Syndrome, may control the onset of aging-associated decline in normal fibroblasts.

Publication types

  • Review
  • Comment

MeSH terms

  • Age Factors
  • Aging / genetics*
  • Cellular Senescence / genetics
  • Cellular Senescence / physiology
  • Fibroblasts / physiology
  • Humans
  • Lamin Type A / genetics*
  • Lamin Type A / metabolism
  • Models, Biological*
  • Progeria / genetics*

Substances

  • LMNA protein, human
  • Lamin Type A