Dominantly transmitted focal dystonia in families of patients with musician's cramp

Neurology. 2006 Aug 22;67(4):691-3. doi: 10.1212/01.wnl.0000230148.00035.f9.

Abstract

Musician's dystonia is generally considered a sporadic disorder. We present three families with the index patient affected by musician's dystonia, but other forms of upper limb focal task-specific dystonia (FTSD), mainly writer's cramp, in seven relatives. Our results suggest a genetic contribution to FTSD with phenotypic variability, including musician's dystonia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Dystonia / epidemiology*
  • Dystonia / genetics*
  • Europe / epidemiology
  • Family
  • Female
  • Genes, Dominant / genetics
  • Genetic Predisposition to Disease / epidemiology
  • Genetic Predisposition to Disease / genetics
  • Heterozygote
  • Humans
  • Male
  • Middle Aged
  • Muscle Cramp / epidemiology*
  • Muscle Cramp / genetics*
  • Music*
  • Occupational Diseases / epidemiology*
  • Occupational Diseases / genetics*
  • Pedigree
  • Pilot Projects
  • Prevalence
  • Risk Assessment
  • Risk Factors