Abstract
An iodinated DNA ligand, iodo Hoechst 33258, which binds in the minor groove of DNA, enhances DNA strand breakage and cell killing by UV-A irradiation. The sites of UV-induced strand breaks reflect the known sequence specificity of the ligand.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Benzimidazoles / pharmacology*
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Bisbenzimidazole / analogs & derivatives
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Bisbenzimidazole / pharmacology*
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Cell Line
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Cell Survival / drug effects
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Cell Survival / radiation effects
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Cricetinae
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DNA / drug effects
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DNA / radiation effects
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DNA Damage
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In Vitro Techniques
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Radiation-Sensitizing Agents / pharmacology*
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Ultraviolet Rays
Substances
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Benzimidazoles
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Radiation-Sensitizing Agents
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2-(2-(3-iodo-4-hydroxyphenyl)-6-benzimidazolyl)-6-(1-methyl-4-piperazyl)benzimidazole
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DNA
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Bisbenzimidazole