Radiation sensitization by an iodine-labelled DNA ligand

Int J Radiat Biol. 1990 May;57(5):939-46. doi: 10.1080/09553009014551061.

Abstract

An iodinated DNA ligand, iodo Hoechst 33258, which binds in the minor groove of DNA, enhances DNA strand breakage and cell killing by UV-A irradiation. The sites of UV-induced strand breaks reflect the known sequence specificity of the ligand.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Benzimidazoles / pharmacology*
  • Bisbenzimidazole / analogs & derivatives
  • Bisbenzimidazole / pharmacology*
  • Cell Line
  • Cell Survival / drug effects
  • Cell Survival / radiation effects
  • Cricetinae
  • DNA / drug effects
  • DNA / radiation effects
  • DNA Damage
  • In Vitro Techniques
  • Radiation-Sensitizing Agents / pharmacology*
  • Ultraviolet Rays

Substances

  • Benzimidazoles
  • Radiation-Sensitizing Agents
  • 2-(2-(3-iodo-4-hydroxyphenyl)-6-benzimidazolyl)-6-(1-methyl-4-piperazyl)benzimidazole
  • DNA
  • Bisbenzimidazole