Novel 5-dimethylamino-1- and 2-indanyl uracil derivatives

J Org Chem. 2006 Sep 1;71(18):7053-6. doi: 10.1021/jo0609881.

Abstract

5-Dimethylamino-1-aminoindan undergoes thermal decomposition and reacts with 6-chlorouracil to give 5-indanyl-6-chlorouracil derivative 9. The formation of 9 may be rationalized by a putative mechanism based on the intermediacy of the imminium methide species 8a.

MeSH terms

  • Chemistry, Organic / methods*
  • Dimethylamines / chemistry*
  • Indans / chemistry
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Uracil / analogs & derivatives
  • Uracil / chemistry*

Substances

  • Dimethylamines
  • Indans
  • Uracil
  • dimethylamine
  • indan