Abstract
Two complexes having the formulas VO(DCIPy)2(H2O).1.5H2O and VO(DCIPy)2(H2O).2MeOH have been synthesized and characterized (DCIPy = 2-(2'-pyridyl)-4,5-dicyanoimidazolato). The methanol solvated species has been studied by X-ray diffraction, and single crystals form in the space group P2(1)/n. The hydrated species was studied by electron paramagnetic resonance spectroscopy in both the solid state and in a frozen solution, and the values of A( parallel) examined using the additivity relationship. The hydrated species was shown to exhibit both spermicidal and cytoxic properties.
MeSH terms
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Antiviral Agents / chemistry
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Antiviral Agents / pharmacology*
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Crystallography, X-Ray
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Fibroblasts / drug effects
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Humans
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Imidazoles / chemistry*
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Male
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Microbial Sensitivity Tests
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Models, Molecular
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Organometallic Compounds / chemistry
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Organometallic Compounds / pharmacology*
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Sperm Motility / drug effects
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Spermatocidal Agents / chemistry
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Spermatocidal Agents / pharmacology*
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Spermatozoa / drug effects
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Structure-Activity Relationship
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Time Factors
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Vanadium / chemistry*
Substances
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2-(2'-pyridyl)-4,5-dicyanoimidazole
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Antiviral Agents
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Imidazoles
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Organometallic Compounds
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Spermatocidal Agents
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Vanadium