Abstract
Chalcones are known to exhibit antimitotic properties caused by inhibition of tubulin polymerisation. We describe here the effects of different alpha-substitutions, in particular alpha-fluorination, on the structure and biological activity of a series of chalcones.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antimitotic Agents / chemical synthesis
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Antimitotic Agents / pharmacology*
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / pharmacology*
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Chalcone / analogs & derivatives
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Chalcone / chemical synthesis
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Chalcone / pharmacology*
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Humans
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K562 Cells
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Structure-Activity Relationship
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Tubulin / metabolism*
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Tumor Cells, Cultured / drug effects*
Substances
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Antimitotic Agents
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Antineoplastic Agents
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Tubulin
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Chalcone