Is celecoxib an inducer of cytochrome P450 3A4 in subjects carrying the CYP2C9*3 allele?

Clin Pharmacol Ther. 2006 Sep;80(3):298-301; author reply 301-02. doi: 10.1016/j.clpt.2006.05.009.
No abstract available

Publication types

  • Letter
  • Comment

MeSH terms

  • Alleles
  • Area Under Curve
  • Aryl Hydrocarbon Hydroxylases / genetics
  • Aryl Hydrocarbon Hydroxylases / metabolism*
  • Celecoxib
  • Cell Line, Tumor
  • Cyclooxygenase 2 Inhibitors / administration & dosage
  • Cyclooxygenase 2 Inhibitors / pharmacokinetics
  • Cytochrome P-450 CYP2C9
  • Cytochrome P-450 CYP3A
  • Cytochrome P-450 Enzyme System / genetics
  • Cytochrome P-450 Enzyme System / metabolism
  • Gene Expression Regulation, Enzymologic / drug effects
  • Humans
  • Pyrazoles / administration & dosage
  • Pyrazoles / pharmacokinetics*
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • Reverse Transcriptase Polymerase Chain Reaction
  • Sulfonamides / administration & dosage
  • Sulfonamides / pharmacokinetics*

Substances

  • Cyclooxygenase 2 Inhibitors
  • Pyrazoles
  • RNA, Messenger
  • Sulfonamides
  • Cytochrome P-450 Enzyme System
  • CYP2C9 protein, human
  • Cytochrome P-450 CYP2C9
  • Aryl Hydrocarbon Hydroxylases
  • Cytochrome P-450 CYP3A
  • CYP3A4 protein, human
  • Celecoxib