Highly efficient Rh(I)-catalyzed asymmetric hydrogenation of enamines using monodente spiro phosphonite ligands

J Am Chem Soc. 2006 Sep 13;128(36):11774-5. doi: 10.1021/ja0644778.

Abstract

A highly enantioselective hydrogenation of nonfunctionalized enamines has been developed by using rhodium complexes of chiral spiro phosphonite ligands, providing chiral tertiary amines in excellent enantioselectivities.

MeSH terms

  • Alkenes / chemistry*
  • Amines / chemical synthesis*
  • Amines / chemistry*
  • Biphenyl Compounds / chemistry
  • Catalysis
  • Hydrogen / chemistry
  • Ligands
  • Organophosphonates / chemistry*
  • Oxidation-Reduction
  • Pyrrolidines / chemistry
  • Rhodium / chemistry
  • Spiro Compounds / chemistry*
  • Stereoisomerism

Substances

  • Alkenes
  • Amines
  • Biphenyl Compounds
  • Ligands
  • Organophosphonates
  • Pyrrolidines
  • Spiro Compounds
  • Hydrogen
  • Rhodium