Abstract
In May 2004 our institution encountered its first clinical isolate of linezolid-resistant, vancomycin-resistant Enterococcus faecium (LRVRE). Between October 2004 and July 2005, 40 patients from whom LRVRE organisms were recovered in clinical specimens were characterized. Epidemiologic investigation and pulsed-field gel electrophoresis patterns indicated a clonal outbreak related to nosocomial spread.
MeSH terms
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Academic Medical Centers
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Acetamides / pharmacology*
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Adult
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Aged
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Aged, 80 and over
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Alabama / epidemiology
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Anti-Infective Agents / pharmacology*
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Cross Infection / epidemiology
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Cross Infection / microbiology
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Cross Infection / transmission*
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Disease Outbreaks*
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Drug Resistance, Multiple, Bacterial* / genetics
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Electrophoresis, Gel, Pulsed-Field
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Enterococcus faecium / drug effects*
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Enterococcus faecium / genetics
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Enterococcus faecium / isolation & purification
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Gram-Positive Bacterial Infections / epidemiology
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Gram-Positive Bacterial Infections / microbiology
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Gram-Positive Bacterial Infections / transmission
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Humans
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Linezolid
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Microbial Sensitivity Tests
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Middle Aged
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Oxazolidinones / pharmacology*
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Vancomycin / pharmacology*
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Vancomycin Resistance
Substances
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Acetamides
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Anti-Infective Agents
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Oxazolidinones
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Vancomycin
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Linezolid