Abstract
We report on a 10-year-old girl with severe aplastic anaemia who developed rhinocerebral infection caused by Absidia corymbifera and a possible co-infection caused by Alternaria alternata. Despite prolonged neutropenia, therapy with liposomal amphotericin B and posaconazole improved the clinical condition. Subsequently, the girl underwent allogeneic haematopoietic stem cell transplantation (HSCT) for the underlying disease, but the fungal infection remained under control with the antifungal treatment. No severe side effect of the antifungal drugs was noted. Unfortunately, the girl died 5 months after HSCT due to disseminated adenovirus infection.
MeSH terms
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Absidia / isolation & purification
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Alternaria / isolation & purification
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Amphotericin B / therapeutic use
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Anemia, Aplastic / complications*
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Anemia, Aplastic / therapy
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Antifungal Agents / therapeutic use
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Central Nervous System Fungal Infections / diagnostic imaging
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Central Nervous System Fungal Infections / drug therapy*
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Central Nervous System Fungal Infections / microbiology
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Child
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Female
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Humans
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Radiography
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Sinusitis / drug therapy*
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Sinusitis / microbiology
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Sinusitis / pathology
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Stem Cell Transplantation / adverse effects*
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Telencephalon / diagnostic imaging
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Telencephalon / microbiology
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Transplantation, Homologous / adverse effects*
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Triazoles / therapeutic use
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Zygomycosis / drug therapy*
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Zygomycosis / microbiology
Substances
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Antifungal Agents
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Triazoles
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liposomal amphotericin B
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posaconazole
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Amphotericin B