Abstract
Trisomy 21 is common in ETV6/RUNX1-positive acute lymphoblastic leukaemia (ALL); both these aberrations are associated with a favourable outcome. The prognostic impact of +21 as a sole cytogenetic change could be due to a cryptic t(12;21)(p13;q22). The occurrence of ETV6/RUNX1 was determined in 66 childhood ALLs with an acquired +21 and a chromosome number <51. ETV6/RUNX1 was found in 45% of cases and in the majority (10/18; 56%) of ALLs with sole +21. Event-free survival did not differ between the t(12;21)-positive and -negative cases. Thus, the prognostic impact of +21 is not attributable to cryptic ETV6/RUNX1.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Burkitt Lymphoma / epidemiology
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Burkitt Lymphoma / genetics*
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Child
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Child, Preschool
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Chromosome Aberrations
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Chromosomes, Human, Pair 21 / genetics*
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Core Binding Factor Alpha 2 Subunit / genetics*
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ETS Translocation Variant 6 Protein
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Female
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Finland / epidemiology
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Genes, Neoplasm / genetics*
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Humans
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Iceland / epidemiology
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Incidence
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Infant
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Male
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Neoplasm Proteins / genetics*
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Prognosis
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Proto-Oncogene Proteins c-ets / genetics*
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Repressor Proteins / genetics*
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Scandinavian and Nordic Countries / epidemiology
Substances
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Core Binding Factor Alpha 2 Subunit
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Neoplasm Proteins
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Proto-Oncogene Proteins c-ets
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RUNX1 protein, human
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Repressor Proteins