Abstract
We report a 29-year-old patient with McArdle's disease and myasthenia gravis. She had been debilitated with McArdle's disease since childhood (with marked rhabdomyolysis) and was obese. Myasthenia gravis was diagnosed at 24 years of age. After 3 months of aerobic exercise training, her exercise capacity increased significantly and she regained the ability to live independently. We conclude that even patients with profound neuromuscular diseases may benefit from carefully prescribed exercise training.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Cell Enlargement
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Creatine Kinase / blood
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Energy Metabolism / physiology
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Exercise / physiology
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Exercise Therapy / methods*
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Exercise Tolerance / physiology
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Female
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Glycogen Phosphorylase, Muscle Form / deficiency
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Glycogen Storage Disease Type V / complications*
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Glycogen Storage Disease Type V / physiopathology
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Glycogen Storage Disease Type V / rehabilitation*
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Humans
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Hypertrophy / metabolism
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Lactic Acid / blood
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Muscle Fibers, Skeletal / cytology
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Muscle Fibers, Skeletal / metabolism
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Muscle, Skeletal / innervation
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Muscle, Skeletal / metabolism
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Muscle, Skeletal / physiopathology
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Myasthenia Gravis / complications*
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Myasthenia Gravis / physiopathology
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Myasthenia Gravis / rehabilitation*
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Neuromuscular Junction / physiopathology
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Oxygen Consumption / physiology
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Physical Fitness / physiology*
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Recovery of Function / physiology
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Treatment Outcome
Substances
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Lactic Acid
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Glycogen Phosphorylase, Muscle Form
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Creatine Kinase