Comparative study of the effect of CV-6209, a specific PAF-antagonist, on rat paw edema caused by different phlogogen agents

Pharmacology. 1990;40(4):211-7. doi: 10.1159/000138661.

Abstract

Comparative effects of CV-6209, a potent and specific platelet activating factor (PAF) antagonist, on PAF-acether-, carrageenin-, histamine-, serotonin-, compound 48/80-, dextran-, zymosan A- and arachidonic acid-induced rat paw edema were investigated. CV-6209 has proven to be effective in PAF-induced edema, but it also showed a significant activity in other models of paw edema, except those induced by zymosan A and arachidonic acid. Other drugs tested, namely indometacin, mepyramine, methysergide and nordihydroguaiaretic acid showed a more selective inhibitory profile. These results suggest an important role of PAF in the inflammatory process caused by intraplantar injection of different phlogogenes in the rat paw.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology
  • Arachidonic Acid
  • Arachidonic Acids
  • Carrageenan
  • Dextrans
  • Edema / chemically induced
  • Edema / diagnosis*
  • Histamine Antagonists
  • Male
  • Platelet Activating Factor / antagonists & inhibitors*
  • Pyridinium Compounds / pharmacology*
  • Rats
  • Rats, Inbred Strains
  • Serotonin Antagonists
  • Zymosan
  • p-Methoxy-N-methylphenethylamine

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Arachidonic Acids
  • Dextrans
  • Histamine Antagonists
  • Platelet Activating Factor
  • Pyridinium Compounds
  • Serotonin Antagonists
  • CV 6209
  • Arachidonic Acid
  • p-Methoxy-N-methylphenethylamine
  • Carrageenan
  • Zymosan