Abstract
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is caused by thymidine phosphorylase (TP) deficiency, which leads to toxic accumulations of thymidine (dThd) and deoxyuridine (dUrd). In this work, we report that infusion of platelets from healthy donors to patients with MNGIE restored transiently circulating TP and reduced plasma dThd and dUrd levels, suggesting that treatments to achieve permanent restoration of circulating TP such as allogeneic stem cell transplantation or gene transfer might be therapeutic.
Publication types
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Case Reports
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Deoxyuridine / antagonists & inhibitors*
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Deoxyuridine / blood
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Female
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Gastrointestinal Diseases / blood
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Gastrointestinal Diseases / therapy*
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Humans
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Male
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Mitochondrial Encephalomyopathies / blood
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Mitochondrial Encephalomyopathies / therapy*
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Nervous System Diseases / blood
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Nervous System Diseases / therapy*
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Platelet Transfusion*
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Thymidine / antagonists & inhibitors*
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Thymidine / blood
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Thymidine Phosphorylase / blood*
Substances
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Thymidine Phosphorylase
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Thymidine
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Deoxyuridine