Abstract
Leptin receptors are expressed on mesolimbic dopamine neurons, yet little is known about the functional significance of this anatomical relationship. In this issue of Neuron, Hommel et al. reveal a novel site for leptin's regulation of feeding. In turn, Fulton et al. propose a novel role for leptin in regulating non-feeding-related motivated behaviors.
MeSH terms
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Animals
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Behavior, Animal / drug effects
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Dopamine / metabolism
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Feeding Behavior / drug effects
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Feeding Behavior / physiology
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Leptin / pharmacology*
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Mesencephalon / cytology
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Mesencephalon / drug effects
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Mesencephalon / metabolism
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Mice
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Models, Biological
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Neurons / drug effects
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Neurons / metabolism
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Neurons / physiology*
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Phosphorylation / drug effects
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Rats
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Receptors, Cell Surface / physiology*
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Receptors, Leptin
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STAT3 Transcription Factor / metabolism
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Signal Transduction / drug effects
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Signal Transduction / physiology*
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Ventral Tegmental Area / cytology
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Ventral Tegmental Area / drug effects
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Ventral Tegmental Area / metabolism
Substances
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Leptin
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Receptors, Cell Surface
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Receptors, Leptin
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STAT3 Transcription Factor
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leptin receptor, mouse
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Dopamine