Rapid emergence of resistance to linezolid during linezolid therapy of an Enterococcus faecium infection

Jamela Seedat; Günther Zick; Ingo Klare; Carola Konstabel; Norbert Weiler; Hany Sahly

doi:10.1128/AAC.00518-06

Rapid emergence of resistance to linezolid during linezolid therapy of an Enterococcus faecium infection

Antimicrob Agents Chemother. 2006 Dec;50(12):4217-9. doi: 10.1128/AAC.00518-06. Epub 2006 Sep 18.

Authors

Jamela Seedat¹, Günther Zick, Ingo Klare, Carola Konstabel, Norbert Weiler, Hany Sahly

Affiliation

¹ Institute for Infection Medicine, University Hospital Schleswig-Holstein, Campus Kiel, Brunswiker Str. 4, D-24105 Kiel, Germany.

Abstract

We report the emergence of linezolid resistance (MICs of 16 to 32 mg/liter) in clonally related vancomycin-susceptible and -resistant Enterococcus faecium isolates from an intensive care unit patient after 12 days of linezolid therapy. Only linezolid-susceptible isolates of the same clone were detected at 28 days after termination of linezolid therapy.

Publication types

Case Reports

MeSH terms

Acetamides / pharmacology*
Acetamides / therapeutic use
Aged
Anti-Bacterial Agents / pharmacology*
Anti-Bacterial Agents / therapeutic use
Drug Resistance, Bacterial
Enterococcus faecium / drug effects*
Enterococcus faecium / isolation & purification
Female
Gram-Positive Bacterial Infections / drug therapy*
Gram-Positive Bacterial Infections / microbiology*
Humans
Intensive Care Units
Linezolid
Microbial Sensitivity Tests
Oxazolidinones / pharmacology*
Oxazolidinones / therapeutic use
Time Factors
Treatment Outcome

Substances

Acetamides
Anti-Bacterial Agents
Oxazolidinones
Linezolid