Abstract
To determine if HIV-1 resistance testing of the blood predicts mutants in the genital secretions of ZDV-treated pregnant women, ZDV resistance mutations were assessed by an oligonucleotide ligation assay. ZDV resistance was detected in viral sequences from blood (16/48; 33%) and cervical secretions (6/24; 25%) collected during 57 pregnancies. The genotype of 11/69 (16%) resistance codons was discordant between blood and cervical virus of pregnant women near term. However, in only 1 (1.8%) of 57 pregnancies evaluated was resistant virus limited to the cervical secretions. ZDV-resistant virus is rarely limited to the female genital tract.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-HIV Agents / pharmacology*
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Biomarkers / blood
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Cervix Mucus / virology
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Drug Resistance, Viral / genetics*
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Drug Resistance, Viral / physiology
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Female
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Genitalia, Female / virology
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HIV Infections / drug therapy
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HIV Infections / prevention & control*
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HIV-1 / drug effects*
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HIV-1 / genetics
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Humans
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Infectious Disease Transmission, Vertical / prevention & control
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Plasma / virology
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Pregnancy
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Pregnancy Complications, Infectious / virology*
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RNA-Directed DNA Polymerase / genetics
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Zidovudine / pharmacology*
Substances
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Anti-HIV Agents
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Biomarkers
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Zidovudine
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RNA-Directed DNA Polymerase