Dopamine transporter and D2 receptor binding densities in mice prone or resistant to chronic high fat diet-induced obesity

Xu-Feng Huang; Katerina Zavitsanou; Xin Huang; Yinghua Yu; HongQin Wang; Feng Chen; Andrew J Lawrence; Chao Deng

doi:10.1016/j.bbr.2006.08.034

Dopamine transporter and D2 receptor binding densities in mice prone or resistant to chronic high fat diet-induced obesity

Behav Brain Res. 2006 Dec 15;175(2):415-9. doi: 10.1016/j.bbr.2006.08.034. Epub 2006 Sep 26.

Authors

Xu-Feng Huang¹, Katerina Zavitsanou, Xin Huang, Yinghua Yu, HongQin Wang, Feng Chen, Andrew J Lawrence, Chao Deng

Affiliation

¹ Department of Biomedical Science, University of Wollongong, NSW 2522, Australia.

PMID: 17000016
DOI: 10.1016/j.bbr.2006.08.034

Abstract

This study examined the density of dopamine transporter (DAT) and D2 receptors in the brains of chronic high-fat diet-induced obese (cDIO), obese-resistant (cDR) and low-fat-fed (LF) control mice. Significantly decreased DAT densities were observed in cDR mice compared to cDIO and LF mice, primarily in the nucleus accumbens, striatal and hypothalamic regions. D2 receptor density was significantly lower in the rostral part of caudate putamen in cDIO mice compared to cDR and LF mice.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Analysis of Variance
Animals
Brain / metabolism*
Dietary Fats
Dopamine Plasma Membrane Transport Proteins / metabolism*
Energy Metabolism / physiology
Hypothalamus / metabolism
Male
Mice
Mice, Inbred C57BL
Neostriatum / metabolism
Nucleus Accumbens / metabolism
Obesity / metabolism*
Random Allocation
Receptors, Dopamine D2 / metabolism*
Statistics, Nonparametric

Substances

Dietary Fats
Dopamine Plasma Membrane Transport Proteins
Receptors, Dopamine D2