Abstract
Clinical, histological, and genetic studies of two cases of isolated fibro-osseous lesions of the femur in adults show the overlap between monostotic fibrous dysplasia (MFD) of the proximal femur and the so-called liposclerosing myxofibrous tumor. The two cases highlight how the incomplete understanding of the natural history of MFD may result in diagnostic pitfalls or incorrect classification of individual lesions.
Publication types
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Case Reports
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Chromogranins
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Diagnosis, Differential
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Female
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Femoral Neoplasms / classification
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Femoral Neoplasms / genetics
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Femoral Neoplasms / pathology*
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Femoral Neoplasms / surgery
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Femur Neck / pathology
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Femur Neck / surgery
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Fibroma / classification
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Fibroma / genetics
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Fibroma / pathology*
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Fibroma / surgery
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Fibrous Dysplasia, Monostotic / classification
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Fibrous Dysplasia, Monostotic / genetics
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Fibrous Dysplasia, Monostotic / pathology*
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Fibrous Dysplasia, Monostotic / surgery
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GTP-Binding Protein alpha Subunits, Gs / genetics
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Humans
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Middle Aged
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Mutation
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Polymorphism, Restriction Fragment Length
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Sclerosis
Substances
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Chromogranins
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GNAS protein, human
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GTP-Binding Protein alpha Subunits, Gs