Report of two cases of aseptic meningitis with persistence of pneumococcal cell wall components in cerebrospinal fluid after Pneumococcal meningitis

François Angoulvant; Julie Lachenaud; Patricia Mariani-Kurkdjian; Guillaume Aubertin; Véronique Houdouin; Mathie Lorrot; Laure de Los Angeles; Edouard Bingen; Antoine Bourrillon; Albert Faye

doi:10.1128/JCM.01120-06

Report of two cases of aseptic meningitis with persistence of pneumococcal cell wall components in cerebrospinal fluid after Pneumococcal meningitis

J Clin Microbiol. 2006 Nov;44(11):4285-7. doi: 10.1128/JCM.01120-06. Epub 2006 Sep 27.

Authors

François Angoulvant¹, Julie Lachenaud, Patricia Mariani-Kurkdjian, Guillaume Aubertin, Véronique Houdouin, Mathie Lorrot, Laure de Los Angeles, Edouard Bingen, Antoine Bourrillon, Albert Faye

Affiliation

¹ Service de Pédiatrie Générale, Hôpital Robert Debré, 48 Boulevard Sérurier, 75019 Paris, France. [email protected]

Abstract

We describe two cases of aseptic meningitis occurring some time after pneumococcal meningitis. Both cases may have resulted from an inflammatory response to persistent pneumococcal cell membrane components, as the cerebrospinal fluid samples were positive by the Binax NOW Streptococcus pneumoniae antigen test. Potential mechanisms and diagnostic impact are discussed.

Publication types

Case Reports

MeSH terms

Antigens, Bacterial / cerebrospinal fluid*
Cell Wall / chemistry
Female
Humans
Infant
Meningitis, Aseptic / cerebrospinal fluid
Meningitis, Aseptic / microbiology*
Meningitis, Pneumococcal / cerebrospinal fluid
Meningitis, Pneumococcal / microbiology*
Polysaccharides, Bacterial / cerebrospinal fluid*

Substances

Antigens, Bacterial
Polysaccharides, Bacterial
polysaccharide C-substance (Streptococcus)