Abstract
Ambruticins are a family of polyketides. The antifungal activity of an ambruticin, KOSN-2079, was tested in the mouse model of invasive aspergillosis. KOSN-2079 significantly reduced pulmonary fungal burdens and improved survival over that with the vehicle control. These results support the continued development of ambruticins as antifungal agents.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antifungal Agents / administration & dosage
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Antifungal Agents / chemistry
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Antifungal Agents / therapeutic use*
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Aspergillosis / drug therapy*
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Aspergillosis / microbiology
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Aspergillosis / mortality
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Aspergillus fumigatus / drug effects*
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Disease Models, Animal*
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Drug Evaluation, Preclinical
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Humans
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Lung Diseases, Fungal / drug therapy*
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Lung Diseases, Fungal / microbiology
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Lung Diseases, Fungal / mortality
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Male
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Mice
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Mice, Inbred BALB C
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Microbial Sensitivity Tests
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Pyrans / administration & dosage
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Pyrans / chemistry
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Pyrans / therapeutic use
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Treatment Outcome
Substances
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Antifungal Agents
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Pyrans
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ambruticin