Abstract
Five isoforms of protein mannosyltransferase (Pmt) O-mannosylate secretory proteins in Candida albicans. pmt mutants were differentially defective for biofilm formation on plastic in static and flow-through systems, and a Pmt inhibitor blocked early stages of biofilm formation. Conceptually, Pmt inhibition may prevent surface anchoring and biofilm-dependent resistance of fungal pathogens.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Biofilms / growth & development*
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Candida albicans / enzymology
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Candida albicans / growth & development*
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Candida albicans / physiology
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Culture Media
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Fungal Proteins / genetics
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Fungal Proteins / metabolism*
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Gene Expression Regulation, Fungal*
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Isoenzymes
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Mannosyltransferases / genetics
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Mannosyltransferases / metabolism*
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Mutation
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Polystyrenes
Substances
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Culture Media
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Fungal Proteins
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Isoenzymes
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Polystyrenes
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Mannosyltransferases
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protein O-mannosyltransferase