Abstract
Scutellaria baicalensis (S.B.) is a widely used Chinese herbal medicine. We initially investigated its in vitro anti-tumor activities. S.B inhibited the growth of ALL, lymphoma and myeloma cell lines by inducing apoptosis and cell cycle arrest at clinically achievable concentrations. The anti-proliferative effect was associated with mitochondrial damage, modulation of the Bcl family of genes, increased level of the CDK inhibitor p27(KIP1) and decreased level of c-myc oncogene. HPLC analysis of S.B. showed it contains 21% baicalin and further studies confirmed it was the major anti-cancer component of S.B. Thus, Scutellaria baicalensis should be tested in clinical trials for these hematopoietic malignancies.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / therapeutic use*
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Apoptosis / drug effects*
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Blotting, Western
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Cell Cycle / drug effects
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Cell Proliferation / drug effects*
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Colony-Forming Units Assay
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Cyclin-Dependent Kinase Inhibitor p27 / metabolism
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Drug Screening Assays, Antitumor
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Drugs, Chinese Herbal / therapeutic use*
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Flavonoids / therapeutic use
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Flow Cytometry
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Humans
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Membrane Potential, Mitochondrial / drug effects
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Multiple Myeloma / drug therapy*
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Multiple Myeloma / metabolism
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Multiple Myeloma / pathology
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / metabolism
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology
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Scutellaria baicalensis / chemistry*
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Tumor Cells, Cultured / drug effects
Substances
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Antineoplastic Agents, Phytogenic
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Drugs, Chinese Herbal
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Flavonoids
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Cyclin-Dependent Kinase Inhibitor p27
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baicalin