Abstract
We present the case of a 74-y-old HIV-negative female who suffered simultaneously from multiple opportunistic infections and a Klebsiella pneumoniae sepsis during high-dose steroids for giant cell arteritis. The patient was treated with a purine analog due to hairy cell leukaemia 10 y previously. Purine analog therapy can lead to long lasting defects in cell-mediated immunity. In these patients, treatment with steroids should be closely monitored with CD4 counts.
MeSH terms
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Aged
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Amphotericin B / therapeutic use
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Anti-Bacterial Agents / therapeutic use
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Anti-Inflammatory Agents / administration & dosage
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Anti-Inflammatory Agents / adverse effects
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Anti-Inflammatory Agents / therapeutic use
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Antifungal Agents / therapeutic use
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Antineoplastic Agents / adverse effects
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Aspergillosis / chemically induced
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Aspergillosis / diagnosis
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Aspergillosis / pathology
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Cladribine / adverse effects*
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Cytomegalovirus / isolation & purification
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Dexamethasone / administration & dosage*
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Dexamethasone / adverse effects*
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Dexamethasone / therapeutic use
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Esophagitis / chemically induced
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Esophagitis / virology
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Female
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Giant Cell Arteritis
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Herpes Simplex / chemically induced
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Humans
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Klebsiella Infections / chemically induced
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Klebsiella Infections / diagnosis
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Klebsiella Infections / pathology
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Klebsiella pneumoniae / isolation & purification
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Leukemia, Hairy Cell
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Methylprednisolone / administration & dosage*
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Methylprednisolone / adverse effects*
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Methylprednisolone / therapeutic use
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Opportunistic Infections / chemically induced*
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Opportunistic Infections / diagnosis
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Opportunistic Infections / microbiology
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Pneumocystis carinii / isolation & purification
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Trimethoprim, Sulfamethoxazole Drug Combination / therapeutic use
Substances
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Anti-Bacterial Agents
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Anti-Inflammatory Agents
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Antifungal Agents
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Antineoplastic Agents
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Cladribine
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Dexamethasone
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Amphotericin B
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Trimethoprim, Sulfamethoxazole Drug Combination
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Methylprednisolone