By using a series of antibodies, we studied the immunohistological hallmarks of eccrine and apocrine sweat glands. Antibodies raised against cytokeratins 6 and 18 decorated the eccrine glands except the acrosyringium. The anti-CEA Ab revealed a uniform and exclusive staining of the eccrine glands. The anti-cytokeratins 8, 18 and 19 Ab labelled the apocrine glands and the secretory part of the eccrine glands. The acrosyringia were revealed by anti-EMA Ab. The immunostaining with anti S-100 protein was positive for the secretory part of the eccrine glands.