Abstract
A new clerodane diterpenoid 16-hydroxycleroda-13-ene-15,16-olide-3-one (1) was isolated from the bark of Polyalthia longifolia var. pendula, along with 23 known compounds and phytosteroids. Among these compounds, 5 - 7, 10, and 24 were obtained for the first time from the family Annonaceae . The structures of the isolated compounds were determined by mass and spectroscopic analysis. The clerodane diterpenoids, 2 - 4, showed significant cytotoxicity towards Hep G2 and Hep 3B hepatoma cell lines. Furthermore, compound 5 exhibited potent anti-inflammatory activity towards formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB)-induced superoxide generation by neutrophils with IC50 = 0.60 +/- 0.09 microg/mL.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
-
Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
-
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
-
Antineoplastic Agents, Phytogenic / administration & dosage
-
Antineoplastic Agents, Phytogenic / pharmacology*
-
Antineoplastic Agents, Phytogenic / therapeutic use
-
Breast Neoplasms / pathology
-
Cell Line, Tumor / drug effects
-
Diterpenes / administration & dosage
-
Diterpenes / pharmacology
-
Diterpenes / therapeutic use
-
Humans
-
Mass Spectrometry
-
Neutrophils / drug effects
-
Phytotherapy*
-
Plant Extracts / administration & dosage
-
Plant Extracts / pharmacology*
-
Plant Extracts / therapeutic use
-
Plant Leaves
-
Polyalthia*
Substances
-
Anti-Inflammatory Agents, Non-Steroidal
-
Antineoplastic Agents, Phytogenic
-
Diterpenes
-
Plant Extracts