Abstract
Conformational analogues of the hydroxamic acid Oxamflatin compounds, have been synthesised to enable evaluation of the impact of varying the linking section on histone deacetylase inhibition. Preliminary testing indicates treatment of leukaemia cells with each of the analogues leads to significant inhibition of histone deacetylase and reduction in cell growth and proliferation.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Biphenyl Compounds / chemical synthesis
-
Biphenyl Compounds / chemistry
-
Cell Survival / drug effects
-
HL-60 Cells
-
Histone Deacetylase Inhibitors*
-
Humans
-
Hydroxamic Acids / chemistry*
-
Hydroxamic Acids / pharmacology*
-
Molecular Conformation
Substances
-
Biphenyl Compounds
-
Histone Deacetylase Inhibitors
-
Hydroxamic Acids
-
oxamflatin