Abstract
To test the role of hepatitis C virus (HCV) in CD4 cell depletion in human immunodeficiency virus (HIV)-coinfected patients, T cell apoptosis was measured by annexin V labeling in 31 HIV-infected and 30 HIV-HCV-coinfected patients who were not receiving antiretroviral therapy. Apoptosis in naive CD4(+) T cells and in naive and memory CD8(+) T cells was significantly higher in HIV-HCV-coinfected than in monoinfected patients.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-HIV Agents / pharmacology*
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Antiretroviral Therapy, Highly Active
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Apoptosis / drug effects*
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CD4 Lymphocyte Count
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CD4-Positive T-Lymphocytes / drug effects
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CD4-Positive T-Lymphocytes / pathology
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CD8-Positive T-Lymphocytes / drug effects
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CD8-Positive T-Lymphocytes / pathology
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HIV Infections / immunology
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HIV Infections / pathology*
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Hepatitis C / immunology
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Hepatitis C / pathology*
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Humans