Abstract
Lung surfactant protein D (SP-D) binds to Mycobacterium tuberculosis surface lipoarabinomannan and results in bacterial agglutination, reduced uptake, and inhibition of growth in human macrophages. Here we show that SP-D limits the intracellular growth of bacilli in macrophages by increasing phagosome-lysosome fusion but not by generating a respiratory burst.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Humans
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Lysosomes / immunology
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Lysosomes / microbiology*
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Lysosomes / ultrastructure
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Macrophages / drug effects*
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Macrophages / immunology*
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Macrophages / ultrastructure
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Membrane Fusion
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Mycobacterium tuberculosis / immunology*
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Phagocytosis
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Phagosomes / immunology
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Phagosomes / microbiology*
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Phagosomes / ultrastructure
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Pulmonary Surfactant-Associated Protein D / pharmacology*
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Rats
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Recombinant Proteins / pharmacology
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Respiratory Burst
Substances
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Pulmonary Surfactant-Associated Protein D
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Recombinant Proteins