Elevated CSF free kappa light chains correlate with disability prognosis in multiple sclerosis

Neurology. 2006 Oct 10;67(7):1288-90. doi: 10.1212/01.wnl.0000238107.31364.21.

Abstract

Elevated CSF free kappa light chains (FKLCs) may predict disability in multiple sclerosis (MS). We reviewed records of 57 patients with MS with 15-year median follow-up for correlations of disability and CSF FKLCs. Levels > or = 1.53 microg/mL predicted progression to need for ambulatory assistance during follow-up (specificity 87.5%, positive predictive value 88.9%) or within 10 years (specificity 78.6%, positive predictive value 66.7%).

Publication types

  • Clinical Trial
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers / cerebrospinal fluid
  • Cohort Studies
  • Disability Evaluation*
  • Female
  • Health Status Indicators*
  • Humans
  • Immunoglobulin kappa-Chains / cerebrospinal fluid*
  • Male
  • Multiple Sclerosis / cerebrospinal fluid*
  • Multiple Sclerosis / diagnosis*
  • Prognosis
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Statistics as Topic

Substances

  • Biomarkers
  • Immunoglobulin kappa-Chains