M13 bacteriophage coat proteins engineered for improved phage display

Methods Mol Biol. 2007:352:205-19. doi: 10.1385/1-59745-187-8:205.

Abstract

This chapter describes a method for increasing levels of protein fusions displayed on the surfaces of M13 bacteriophage particles. By introducing mutations into the anchoring M13 coat protein, protein display levels can be increased by up to two orders of magnitude. Experimental methods are presented for the design, construction, and screening of phage-displayed libraries for improved protein display.

MeSH terms

  • Capsid Proteins / chemistry*
  • Capsid Proteins / genetics*
  • Capsid Proteins / metabolism
  • Models, Molecular
  • Mutation
  • Peptide Library*
  • Protein Engineering*

Substances

  • Capsid Proteins
  • Peptide Library
  • coat protein, Bacteriophage M13