Abstract
The pharmacokinetic profile of linezolid in cerebrospinal fluid (CSF) in five neurointensive care patients with staphylococcal ventriculitis was studied. The mean area under concentration-time curve (+/- standard deviation) was 63 +/- 18.9 mg x h/liter, with a CSF-to-plasma ratio of 0.8 +/- 0.3. Times above MIC in CSF were 99.8% and 57.2% for pathogens with MICs of 2 mg/liter and 4 mg/liter, respectively.
Publication types
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Clinical Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetamides / blood
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Acetamides / cerebrospinal fluid
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Acetamides / pharmacokinetics*
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Adolescent
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Adult
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Aged
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Area Under Curve
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Cerebral Ventricles / drug effects*
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Cerebral Ventricles / metabolism
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Cerebral Ventricles / microbiology
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Encephalitis / drug therapy*
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Encephalitis / metabolism
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Encephalitis / microbiology
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Female
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Humans
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Injections, Intravenous
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Linezolid
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Male
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Metabolic Clearance Rate
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Microbial Sensitivity Tests
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Middle Aged
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Oxazolidinones / blood
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Oxazolidinones / cerebrospinal fluid
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Oxazolidinones / pharmacokinetics*
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Staphylococcal Infections / drug therapy*
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Staphylococcal Infections / microbiology
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Staphylococcus / drug effects*
Substances
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Acetamides
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Oxazolidinones
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Linezolid