Application of an improved column characterisation system to evaluate the within and between batch variability

J Pharm Biomed Anal. 2007 Jul 27;44(3):634-9. doi: 10.1016/j.jpba.2006.08.017. Epub 2006 Oct 10.

Abstract

The selection of a reversed-phase liquid chromatographic column with suitable selectivity for a particular separation is difficult if the brand name of the column is not known. A project to develop a chromatographic test procedure to characterize reversed-phase liquid chromatography C18 columns was started earlier and resulted in a fast, simple, repeatable and reproducible test procedure using four column parameters. Here, this procedure is used to evaluate the diversity of columns originating from the same batch as well as from different batches. The determination of one of the parameters, the retention factor of 2,2'-dipyridyl, was improved and a simplified test procedure is proposed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 2,2'-Dipyridyl / analysis
  • Chromatography, High Pressure Liquid / instrumentation*
  • Chromatography, High Pressure Liquid / methods
  • Reproducibility of Results
  • Time Factors

Substances

  • 2,2'-Dipyridyl