Abstract
Cardiomyopathy due to iron overload represents a frequent life-limiting complication in patients with beta-thalassemia major. We have conducted a study which proved that brain natriuretic peptide plasma levels have high sensitivity and negative predictive value in detecting cardiac hemosiderosis.
MeSH terms
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Adult
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Biomarkers / blood
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Blood Transfusion / methods
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Cardiomyopathies / diagnosis*
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Cardiomyopathies / etiology
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Cohort Studies
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Female
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Hemosiderosis / diagnosis
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Humans
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Iron Overload / diagnosis*
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Male
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Natriuretic Peptide, Brain / blood*
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Natriuretic Peptide, Brain / metabolism
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Predictive Value of Tests
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Probability
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Prognosis
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Sensitivity and Specificity
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Severity of Illness Index
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beta-Thalassemia / complications*
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beta-Thalassemia / diagnosis
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beta-Thalassemia / therapy
Substances
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Biomarkers
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Natriuretic Peptide, Brain