Tetrahydroquinoline sulfonamides as gamma-secretase inhibitors

Theodros Asberom; Thomas A Bara; John W Clader; William J Greenlee; Henry S Guzik; Hubert B Josien; Wei Li; Eric M Parker; Dmitri A Pissarnitski; Lixin Song; Lili Zhang; Zhiqiang Zhao

doi:10.1016/j.bmcl.2006.09.064

Tetrahydroquinoline sulfonamides as gamma-secretase inhibitors

Bioorg Med Chem Lett. 2007 Jan 1;17(1):205-7. doi: 10.1016/j.bmcl.2006.09.064. Epub 2006 Oct 12.

Authors

Theodros Asberom¹, Thomas A Bara, John W Clader, William J Greenlee, Henry S Guzik, Hubert B Josien, Wei Li, Eric M Parker, Dmitri A Pissarnitski, Lixin Song, Lili Zhang, Zhiqiang Zhao

Affiliation

¹ Department of Chemical Research, Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. [email protected]

PMID: 17046254
DOI: 10.1016/j.bmcl.2006.09.064

Abstract

The development of a novel series of tetrahydroquinoline-derived gamma-secretase inhibitors for the potential treatment of Alzheimer's disease is described.

MeSH terms

Alzheimer Disease / drug therapy*
Amyloid Precursor Protein Secretases / antagonists & inhibitors*
Humans
Protease Inhibitors / chemical synthesis
Protease Inhibitors / chemistry*
Quinolines / chemical synthesis
Quinolines / chemistry*
Structure-Activity Relationship
Sulfonamides / chemical synthesis
Sulfonamides / chemistry*

Substances

Protease Inhibitors
Quinolines
Sulfonamides
Amyloid Precursor Protein Secretases