Stereoselective synthesis of N-alkylaziridines from N-chloroamines

Chem Commun (Camb). 2006 Nov 4:(41):4338-40. doi: 10.1039/b608504k. Epub 2006 Sep 5.

Abstract

We report the first racemic and stereoselective synthesis of cis- and trans-N-alkylaziridines viaN-chloroamines; using this methodology an N-3,4,5-trimethoxybenzylaziridine was synthesised and efficiently cleaved, affording the corresponding NH aziridine in high yield.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aziridines / chemistry*
  • Catalysis
  • Chloramines / chemical synthesis*
  • Cyclization
  • Molecular Structure
  • Solvents
  • Stereoisomerism

Substances

  • Aziridines
  • Chloramines
  • Solvents
  • aziridine