Differential regulation of hepatic apoptotic pathways by dietary olive and sunflower oils in the aging rat

Exp Gerontol. 2006 Nov;41(11):1174-84. doi: 10.1016/j.exger.2006.08.012. Epub 2006 Oct 17.

Abstract

In this work we have studied how dietary fat affects aging-related changes in a number of factors that regulate rat hepatic apoptosis. Animals were fed lifelong with two experimental diets containing either virgin olive oil or sunflower oil as dietary fat. Caspases of the intrinsic and extrinsic pathways of apoptosis, Bcl-2 and Bax polypeptide levels, and plasma membrane neutral sphingomyelinase activity were determined at 6, 12, and 24 months of age. Caspase-8/10 activity (a marker of the extrinsic pathway) was not affected by either aging or dietary fat, but activities of both caspase-9 (a marker of the intrinsic pathway) and caspase-3 (an executioner caspase) were significantly depressed in liver from animals fed on a sunflower oil-based diet. These decreases were not observed in animals fed with a diet based on virgin olive oil, which also resulted in significantly lower Bcl-2/Bax ratios. On the other hand, in comparison with sunflower, dietary olive oil decreased oxidative stress in liver from aged rats, resulting in lower levels of membrane hydroperoxides and higher coenzyme Q levels in plasma membrane. Plasma membrane Mg(2+)-dependent neutral sphingomyelinase was strongly activated in aged rats fed on the sunflower oil diet, but no aging-related increase was observed in animals fed on the olive oil diet. Our results support that dietary oil can alter significantly the susceptibility of hepatocytes to different apoptotic stimuli by altering both pro- and anti-apoptotic mediators, which reinforces the importance of the diet in aging studies. Because virgin olive oil may increase susceptibility of hepatocytes to apoptosis induced through the intrinsic pathway under conditions of decreased oxidative stress, our results may have important implications to understand the potential beneficial effects of that edible oil against liver carcinogenesis during aging.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging / metabolism
  • Aging / physiology*
  • Animals
  • Apoptosis / physiology*
  • Caspases / metabolism
  • Cell Membrane / metabolism
  • Dietary Fats, Unsaturated / administration & dosage*
  • Lipid Peroxides / analysis
  • Liver / metabolism
  • Liver / physiology*
  • Male
  • Olive Oil
  • Oxidative Stress / physiology
  • Plant Oils / administration & dosage*
  • Proto-Oncogene Proteins c-bcl-2 / analysis
  • Rats
  • Rats, Wistar
  • Sphingomyelin Phosphodiesterase / analysis
  • Sunflower Oil
  • Ubiquinone / analysis
  • bcl-2-Associated X Protein / analysis

Substances

  • Dietary Fats, Unsaturated
  • Lipid Peroxides
  • Olive Oil
  • Plant Oils
  • Proto-Oncogene Proteins c-bcl-2
  • Sunflower Oil
  • bcl-2-Associated X Protein
  • Ubiquinone
  • Sphingomyelin Phosphodiesterase
  • Caspases